NAD(+) replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair

Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand breaks. The molecular basis of cerebellar atrophy an...

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Publicado no:Cell Metab
Main Authors: Fang, Evandro Fei, Kassahun, Henok, Croteau, Deborah L., Scheibye-Knudsen, Morten, Marosi, Krisztina, Lu, Huiming, Shamanna, Raghavendra A., Kalyanasundaram, Sumana, Bollineni, Ravi Chand, Wilson, Mark A., Iser, Wendy B., Wollman, Bradley N., Morevati, Marya, Li, Jun, Kerr, Jesse S., Lu, Qiping, Waltz, Tyler B., Tian, Jane, Sinclair, David A., Mattson, Mark P., Nilsen, Hilde, Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777858/
https://ncbi.nlm.nih.gov/pubmed/27732836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.004
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