NAD(+) replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair

Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response to and repair of DNA double-strand breaks. The molecular basis of cerebellar atrophy an...

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Vydáno v:Cell Metab
Hlavní autoři: Fang, Evandro Fei, Kassahun, Henok, Croteau, Deborah L., Scheibye-Knudsen, Morten, Marosi, Krisztina, Lu, Huiming, Shamanna, Raghavendra A., Kalyanasundaram, Sumana, Bollineni, Ravi Chand, Wilson, Mark A., Iser, Wendy B., Wollman, Bradley N., Morevati, Marya, Li, Jun, Kerr, Jesse S., Lu, Qiping, Waltz, Tyler B., Tian, Jane, Sinclair, David A., Mattson, Mark P., Nilsen, Hilde, Bohr, Vilhelm A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777858/
https://ncbi.nlm.nih.gov/pubmed/27732836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.09.004
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