Nicotinamide improves aspects of healthspan but not lifespan in mice

The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan measures in mice without extending lifespan. Untargeted metabolite profiling of the liver and metabolic flux analysis of l...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Mitchell, Sarah J., Bernier, Michel, Aon, Miguel A., Cortassa, Sonia, Kim, Eun Young, Fang, Evandro F., Palacios, Hector H., Ali, Ahmed, Navas-Enamorado, Ignacio, Di Francesco, Andrea, Kaiser, Tamzin A., Waltz, Tyler B., Zhang, Ning, Ellis, James L., Elliott, Peter J., Frederick, David W., Bohr, Vilhelm A., Schmidt, Mark S., Brenner, Charles, Sinclair, David A., Sauve, Anthony A., Baur, Joseph A., de Cabo, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854409/
https://ncbi.nlm.nih.gov/pubmed/29514072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.02.001
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