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Early sensitization of myofilaments to Ca(2+) prevents genetically linked dilated cardiomyopathy in mice
BACKGROUND: Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac chambers and a major cause of morbidity and mortality. Mice with Glu54Lys mutation in α-tropomyosin (Tm54) demonstrate typical D...
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| Pubblicato in: | Cardiovasc Res |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5852625/ https://ncbi.nlm.nih.gov/pubmed/28379313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx068 |
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