Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a “disease of the sarcomere.” Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms respo...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Chowdhury, Shamim A. K., Warren, Chad M., Simon, Jillian N., Ryba, David M., Batra, Ashley, Varga, Peter, Kranias, Evangelia G., Tardiff, Jil C., Solaro, R. John, Wolska, Beata M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075858/
https://ncbi.nlm.nih.gov/pubmed/32210830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00107
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