Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca(2+) Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K

Apart from transplant, there are no satisfactory therapies for the severe depression in contractility in familial dilated cardiomyopathy (DCM). Current heart failure treatments that act by increasing contractility involve signaling cascades that alter calcium homeostasis and induce arrhythmias. Omec...

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Vydáno v:J Cardiovasc Pharmacol
Hlavní autoři: Utter, Megan S., Ryba, David M., Li, Betty H., Wolska, Beata M., Solaro, R. John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460532/
https://ncbi.nlm.nih.gov/pubmed/26065842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000286
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