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Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca(2+) Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K
Apart from transplant, there are no satisfactory therapies for the severe depression in contractility in familial dilated cardiomyopathy (DCM). Current heart failure treatments that act by increasing contractility involve signaling cascades that alter calcium homeostasis and induce arrhythmias. Omec...
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| Publicado no: | J Cardiovasc Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5460532/ https://ncbi.nlm.nih.gov/pubmed/26065842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000286 |
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