Early sensitization of myofilaments to Ca(2+) prevents genetically linked dilated cardiomyopathy in mice

BACKGROUND: Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac chambers and a major cause of morbidity and mortality. Mice with Glu54Lys mutation in α-tropomyosin (Tm54) demonstrate typical D...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Alves, Marco L., Warren, Chad M., Simon, Jillian N., Gaffin, Robert D., Montminy, Eric M., Wieczorek, David F., Solaro, R. John, Wolska, Beata M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852625/
https://ncbi.nlm.nih.gov/pubmed/28379313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx068
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