Desensitization of Myofilaments to Ca(2+) as a Therapeutic Target for Hypertrophic Cardiomyopathy with Mutations in Thin Filament Proteins

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca(2+) sensitivity and high susceptibility to sudden death. We teste...

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Autores principales: Alves, Marco L., Dias, Fernando A.L., Gaffin, Robert D., Simon, Jillian N., Montminy, Eric M., Biesiadecki, Brandon J., Hinken, Aaron C., Warren, Chad M., Utter, Megan S., Davis, Robert T., Sakthivel, Sadayappan, Robbins, Jeffrey, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061696/
https://ncbi.nlm.nih.gov/pubmed/24585742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000324
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