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Desensitization of Myofilaments to Ca(2+) as a Therapeutic Target for Hypertrophic Cardiomyopathy with Mutations in Thin Filament Proteins
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca(2+) sensitivity and high susceptibility to sudden death. We teste...
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| Główni autorzy: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4061696/ https://ncbi.nlm.nih.gov/pubmed/24585742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000324 |
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