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Desensitization of Myofilaments to Ca(2+) as a Therapeutic Target for Hypertrophic Cardiomyopathy with Mutations in Thin Filament Proteins

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca(2+) sensitivity and high susceptibility to sudden death. We teste...

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書誌詳細
主要な著者: Alves, Marco L., Dias, Fernando A.L., Gaffin, Robert D., Simon, Jillian N., Montminy, Eric M., Biesiadecki, Brandon J., Hinken, Aaron C., Warren, Chad M., Utter, Megan S., Davis, Robert T., Sakthivel, Sadayappan, Robbins, Jeffrey, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061696/
https://ncbi.nlm.nih.gov/pubmed/24585742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000324
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