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Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil

We investigated a dilated cardiomyopathy (DCM) mutation (F764L) in human β-cardiac myosin by determining its motor properties in the presence and absence of the heart failure drug omecamtive mecarbil (OM). The mutation is located in the converter domain, a key region of communication between the cat...

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Pubblicato in:J Biol Chem
Autori principali: Tang, Wanjian, Unrath, William C., Desetty, Rohini, Yengo, Christopher M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873177/
https://ncbi.nlm.nih.gov/pubmed/31578282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010217
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