Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

The small molecule drug omecamtiv mecarbil (OM) specifically targets cardiac muscle myosin and is known to enhance cardiac muscle performance, yet its impact on human cardiac myosin motor function is unclear. We expressed and purified human β-cardiac myosin subfragment 1 (M2β-S1) containing a C-term...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Swenson, Anja M., Tang, Wanjian, Blair, Cheavar A., Fetrow, Christopher M., Unrath, William C., Previs, Michael J., Campbell, Kenneth S., Yengo, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339759/
https://ncbi.nlm.nih.gov/pubmed/28082673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748780
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge