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Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
Omecamtiv mecarbil (OM) is a putative positive inotropic tool for treatment of systolic heart dysfunction, based on the finding that in vivo it increases the ejection fraction and in vitro it prolongs the actin-bond life time of the cardiac and slow-skeletal muscle isoforms of myosin. OM action in s...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7341760/ https://ncbi.nlm.nih.gov/pubmed/32636378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17143-2 |
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