Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

The small molecule drug omecamtiv mecarbil (OM) specifically targets cardiac muscle myosin and is known to enhance cardiac muscle performance, yet its impact on human cardiac myosin motor function is unclear. We expressed and purified human β-cardiac myosin subfragment 1 (M2β-S1) containing a C-term...

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Vydáno v:J Biol Chem
Hlavní autoři: Swenson, Anja M., Tang, Wanjian, Blair, Cheavar A., Fetrow, Christopher M., Unrath, William C., Previs, Michael J., Campbell, Kenneth S., Yengo, Christopher M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339759/
https://ncbi.nlm.nih.gov/pubmed/28082673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748780
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