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N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy

S-glutathionylation of cardiac myosin-binding protein C (cMyBP-C) induces Ca(2+) sensitization and a slowing of cross-bridge kinetics as a result of increased oxidative signaling. Although there is evidence for a role of oxidative stress in disorders associated with hypertrophic cardiomyopathy (HCM)...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Wilder, Tanganyika, Ryba, David M., Wieczorek, David F., Wolska, Beata M., Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666985/
https://ncbi.nlm.nih.gov/pubmed/26432840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00339.2015
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