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The Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G mouse model linked to Hypertrophic Cardiomyopathy
BACKGROUND. Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with hypertrophy, diastolic dysfunction and fibrosis, but there is no specific treatment. The sphringosine-1-phosphate receptor modulator, FT...
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| Publicat a: | Circ Heart Fail |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6857720/ https://ncbi.nlm.nih.gov/pubmed/31684756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005835 |
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