The Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G mouse model linked to Hypertrophic Cardiomyopathy

BACKGROUND. Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with hypertrophy, diastolic dysfunction and fibrosis, but there is no specific treatment. The sphringosine-1-phosphate receptor modulator, FT...

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Udgivet i:Circ Heart Fail
Main Authors: Ryba, David M., Warren, Chad M., Karam, Chehade N., Davis, Robert T., Chowdhury, Shamim A. K., Alvarez, Manuel G., McCann, Maximilian, Liew, Chong Wee, Wieczorek, David F., Varga, Peter, Solaro, R. John, Wolska, Beata M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857720/
https://ncbi.nlm.nih.gov/pubmed/31684756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005835
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