The Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G mouse model linked to Hypertrophic Cardiomyopathy

BACKGROUND. Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with hypertrophy, diastolic dysfunction and fibrosis, but there is no specific treatment. The sphringosine-1-phosphate receptor modulator, FT...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Circ Heart Fail
Prif Awduron: Ryba, David M., Warren, Chad M., Karam, Chehade N., Davis, Robert T., Chowdhury, Shamim A. K., Alvarez, Manuel G., McCann, Maximilian, Liew, Chong Wee, Wieczorek, David F., Varga, Peter, Solaro, R. John, Wolska, Beata M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857720/
https://ncbi.nlm.nih.gov/pubmed/31684756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005835
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