Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivity is still under debate. Here, we probe the trans...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ananth, Adithya N, Mishra, Ankur, Frey, Steffen, Dwarkasing, Arvind, Versloot, Roderick, van der Giessen, Erik, Görlich, Dirk, Onck, Patrick, Dekker, Cees
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826291/
https://ncbi.nlm.nih.gov/pubmed/29442997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31510
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