Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsib...

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Vydáno v:Cell
Hlavní autoři: Seegar, Tom C.M., Killingsworth, Lauren B., Saha, Nayanendu, Meyer, Peter A., Patra, Dhabaleswar, Zimmerman, Brandon, Janes, Peter W., Rubinstein, Eric, Nikolov, Dimitar B., Skiniotis, Georgios, Kruse, Andrew C., Blacklow, Stephen C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773094/
https://ncbi.nlm.nih.gov/pubmed/29224781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.014
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