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Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsib...

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Bibliografiska uppgifter
I publikationen:	Cell
Huvudupphovsmän:	Seegar, Tom C.M., Killingsworth, Lauren B., Saha, Nayanendu, Meyer, Peter A., Patra, Dhabaleswar, Zimmerman, Brandon, Janes, Peter W., Rubinstein, Eric, Nikolov, Dimitar B., Skiniotis, Georgios, Kruse, Andrew C., Blacklow, Stephen C.
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	2017
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5773094/ https://ncbi.nlm.nih.gov/pubmed/29224781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.014
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Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

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