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ADAM proteases: Emerging role and targeting of the non-catalytic domains

ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. Consequently, they have emerged as key therapeutic targets in t...

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Detalles Bibliográficos
Publicado en:Cancer Lett
Autores principales: Saha, Nayanendu, Robev, Dorothea, Himanen, Juha P., Nikolov, Dimitar B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485987/
https://ncbi.nlm.nih.gov/pubmed/31593799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.10.003
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