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ADAM proteases: Emerging role and targeting of the non-catalytic domains

ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. Consequently, they have emerged as key therapeutic targets in t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Lett
Main Authors: Saha, Nayanendu, Robev, Dorothea, Himanen, Juha P., Nikolov, Dimitar B.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485987/
https://ncbi.nlm.nih.gov/pubmed/31593799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.10.003
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