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ADAM proteases: Emerging role and targeting of the non-catalytic domains

ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. Consequently, they have emerged as key therapeutic targets in t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Lett
Hauptverfasser: Saha, Nayanendu, Robev, Dorothea, Himanen, Juha P., Nikolov, Dimitar B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485987/
https://ncbi.nlm.nih.gov/pubmed/31593799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.10.003
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