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ADAM proteases: Emerging role and targeting of the non-catalytic domains
ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. Consequently, they have emerged as key therapeutic targets in t...
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| Veröffentlicht in: | Cancer Lett |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7485987/ https://ncbi.nlm.nih.gov/pubmed/31593799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.10.003 |
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