Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

The ADAM10 transmembrane metalloprotease cleaves a variety of cell surface proteins that are important in disease, including ligands for receptor tyrosine kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-medi...

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Bibliographic Details
Main Authors: Atapattu, Lakmali, Saha, Nayanendu, Llerena, Carmen, Vail, Mary E., Scott, Andrew M., Nikolov, Dimitar B., Lackmann, Martin, Janes, Peter W.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585520/
https://ncbi.nlm.nih.gov/pubmed/23108669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.112631
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