Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsib...

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Veröffentlicht in:Cell
Hauptverfasser: Seegar, Tom C.M., Killingsworth, Lauren B., Saha, Nayanendu, Meyer, Peter A., Patra, Dhabaleswar, Zimmerman, Brandon, Janes, Peter W., Rubinstein, Eric, Nikolov, Dimitar B., Skiniotis, Georgios, Kruse, Andrew C., Blacklow, Stephen C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773094/
https://ncbi.nlm.nih.gov/pubmed/29224781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.014
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