Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

Many studies have revealed pathways of epigenetic gene silencing by Polycomb Repressive Complex 2 (PRC2) in vivo, but understanding molecular mechanisms requires biochemistry. Here we analyze reconstituted human PRC2-nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclus...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Wang, Xueyin, Paucek, Richard D., Gooding, Anne R., Brown, Zachary Z., Ge, Eva J., Muir, Tom W., Cech, Thomas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771497/
https://ncbi.nlm.nih.gov/pubmed/29058709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3487
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