Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

Many studies have revealed pathways of epigenetic gene silencing by Polycomb Repressive Complex 2 (PRC2) in vivo, but understanding molecular mechanisms requires biochemistry. Here we analyze reconstituted human PRC2-nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclus...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Struct Mol Biol
Main Authors: Wang, Xueyin, Paucek, Richard D., Gooding, Anne R., Brown, Zachary Z., Ge, Eva J., Muir, Tom W., Cech, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771497/
https://ncbi.nlm.nih.gov/pubmed/29058709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3487
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker