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Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 using a Surrogate of Heterotypic Chromatin

Eukaryotic genomes are dynamically regulated through a host of epigenetic stimuli. The substrate for these epigenetic transactions, chromatin, is a polymer of nucleosome building blocks. In native (i.e. cellular) chromatin, each nucleosome can differ from its neighbors through the localized installa...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Brown, Zachary Z., Müller, Manuel M., Kong, Ha Eun, Lewis, Peter W., Muir, Tom W.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617617/
https://ncbi.nlm.nih.gov/pubmed/25873363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201500085
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