Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase

Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2), the enzyme that catalyzes monomethylation, dimethylation, and trimethylation of lysine 27 on histone H3 (H3K27). Trimethylation at H3K27 (H3K27me3) is associated with transcriptional silencing of deve...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jani, Krupa S., Jain, Siddhant U., Ge, Eva J., Diehl, Katharine L., Lundgren, Stefan M., Müller, Manuel M., Lewis, Peter W., Muir, Tom W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486736/
https://ncbi.nlm.nih.gov/pubmed/30967505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819029116
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