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Regulation of histone methylation by automethylation of PRC2

Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that is critical for regulating transcriptional repression in mammals. Its catalytic subunit, EZH2, is responsible for the trimethylation of H3K27 and also undergoes automethylation. Using mass spectrometry analysis of recombinant h...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Wang, Xueyin, Long, Yicheng, Paucek, Richard D., Gooding, Anne R., Lee, Thomas, Burdorf, Rachel M., Cech, Thomas R.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771386/
https://ncbi.nlm.nih.gov/pubmed/31488576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328849.119
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