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Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
Many studies have revealed pathways of epigenetic gene silencing by Polycomb Repressive Complex 2 (PRC2) in vivo, but understanding molecular mechanisms requires biochemistry. Here we analyze reconstituted human PRC2-nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclus...
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| Publicado en: | Nat Struct Mol Biol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771497/ https://ncbi.nlm.nih.gov/pubmed/29058709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3487 |
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