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Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that promotes epigenetic gene silencing, but the dynamics of its interactions with chromatin are largely unknown. Here we quantitatively measured the binding of PRC2 to chromatin in human cancer cells. Genome editing of a HaloTag in...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Youmans, Daniel T., Schmidt, Jens C., Cech, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049511/
https://ncbi.nlm.nih.gov/pubmed/29891558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311936.118
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