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Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that promotes epigenetic gene silencing, but the dynamics of its interactions with chromatin are largely unknown. Here we quantitatively measured the binding of PRC2 to chromatin in human cancer cells. Genome editing of a HaloTag in...

詳細記述

保存先:
書誌詳細
出版年:Genes Dev
主要な著者: Youmans, Daniel T., Schmidt, Jens C., Cech, Thomas R.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049511/
https://ncbi.nlm.nih.gov/pubmed/29891558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311936.118
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