Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that promotes epigenetic gene silencing, but the dynamics of its interactions with chromatin are largely unknown. Here we quantitatively measured the binding of PRC2 to chromatin in human cancer cells. Genome editing of a HaloTag in...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Youmans, Daniel T., Schmidt, Jens C., Cech, Thomas R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049511/
https://ncbi.nlm.nih.gov/pubmed/29891558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311936.118
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