Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma

The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been shown to automethylate its core subunits, EZH1/EZH2 and SUZ12. Here, we identify the lysine residues at which EZH1/EZH2 are auto...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Lee, Chul-Hwan, Yu, Jia-Ray, Granat, Jeffrey, Saldaña-Meyer, Ricardo, Andrade, Joshua, LeRoy, Gary, Jin, Ying, Lund, Peder, Stafford, James M., Garcia, Benjamin A., Ueberheide, Beatrix, Reinberg, Danny
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771381/
https://ncbi.nlm.nih.gov/pubmed/31488577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328773.119
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