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Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been shown to automethylate its core subunits, EZH1/EZH2 and SUZ12. Here, we identify the lysine residues at which EZH1/EZH2 are auto...
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| Опубликовано в: : | Genes Dev |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6771381/ https://ncbi.nlm.nih.gov/pubmed/31488577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328773.119 |
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