The H3K36me2 writer-reader dependency in H3K27M-DIPG

Histone H3K27M is a driving mutation in diffuse intrinsic pontine glioma (DIPG), a deadly pediatric brain tumor. H3K27M reshapes the epigenome through a global inhibition of PRC2 catalytic activity and displacement of H3K27me2/3, promoting oncogenesis of DIPG. As a consequence, a histone modificatio...

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Publicat a:Sci Adv
Autors principals: Yu, Jia-Ray, LeRoy, Gary, Bready, Devin, Frenster, Joshua D., Saldaña-Meyer, Ricardo, Jin, Ying, Descostes, Nicolas, Stafford, James M., Placantonakis, Dimitris G., Reinberg, Danny
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279504/
https://ncbi.nlm.nih.gov/pubmed/34261657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg7444
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