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The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation
The Sotos syndrome gene product, NSD1, is a SET domain histone methyltransferase that primarily dimethylates nucleosomal histone H3 lysine 36 (H3K36). To date, the intrinsic properties of NSD1 that determine its nucleosomal substrate selectivity and dimethyl H3K36 product specificity remain unknown....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048720/ https://ncbi.nlm.nih.gov/pubmed/21196496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204115 |
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