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Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases
The NSD family histone methyltransferases, including NSD1, NSD2 and NSD3, play crucial roles in chromatin regulation and are implicated in oncogenesis(1,2). NSD enzymes exhibit an auto-inhibitory state that is relieved by nucleosome engagement, allowing for H3K36 di-methylation catalysis(3–7). Howev...
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| Опубликовано в: : | Nature |
|---|---|
| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7889650/ https://ncbi.nlm.nih.gov/pubmed/33361816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03069-8 |
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