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Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases

Altered chromatin structures and dynamics are responsible for a range of human malignancies, among which the status of histone lysine methylation remains of paramount importance. Histone lysine methylation is maintained by the relative activities of sequence-specific methyltransferase (KMT) writers...

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Bibliografiska uppgifter
I publikationen:Q Rev Biophys
Huvudupphovsmän: Wang, Zhanxin, Patel, Dinshaw J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696758/
https://ncbi.nlm.nih.gov/pubmed/23991894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033583513000085
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