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Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases
Altered chromatin structures and dynamics are responsible for a range of human malignancies, among which the status of histone lysine methylation remains of paramount importance. Histone lysine methylation is maintained by the relative activities of sequence-specific methyltransferase (KMT) writers...
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| Опубликовано в: : | Q Rev Biophys |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4696758/ https://ncbi.nlm.nih.gov/pubmed/23991894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033583513000085 |
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