Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

The NSD family histone methyltransferases, including NSD1, NSD2 and NSD3, play crucial roles in chromatin regulation and are implicated in oncogenesis(1,2). NSD enzymes exhibit an auto-inhibitory state that is relieved by nucleosome engagement, allowing for H3K36 di-methylation catalysis(3–7). Howev...

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Gepubliceerd in:Nature
Hoofdauteurs: Li, Wanqiu, Tian, Wei, Yuan, Gang, Deng, Pujuan, Sengupta, Deepanwita, Cheng, Zhongjun, Cao, Yinghua, Ren, Jiahao, Qin, Yan, Zhou, Yuqiao, Jia, Yulin, Gozani, Or, Patel, Dinshaw J., Wang, Zhanxin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889650/
https://ncbi.nlm.nih.gov/pubmed/33361816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03069-8
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