Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf–Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer, there are no potent, selective inhibitors of thi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Poulin, Myles B., Schneck, Jessica L., Matico, Rosalie E., McDevitt, Patrick J., Huddleston, Michael J., Hou, Wangfang, Johnson, Neil W., Thrall, Sara H., Meek, Thomas D., Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747696/
https://ncbi.nlm.nih.gov/pubmed/26787850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521036113
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