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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enz...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3222870/ https://ncbi.nlm.nih.gov/pubmed/22099308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.042 |
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