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PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor

A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this “oncohistone” mutation acts by inhibiting the histone methyltransferase PRC2, the details of this proposed mechanism neverthele...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Diehl, Katharine L., Ge, Eva J., Weinberg, Daniel N., Jani, Krupa S., Allis, C. David, Muir, Tom W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825254/
https://ncbi.nlm.nih.gov/pubmed/31611394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911775116
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