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PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this “oncohistone” mutation acts by inhibiting the histone methyltransferase PRC2, the details of this proposed mechanism neverthele...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825254/ https://ncbi.nlm.nih.gov/pubmed/31611394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911775116 |
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