Oncogenic Mechanisms of Histone H3 Mutations

por Weinberg, Daniel N., Allis, C. David, Lu, Chao
Publicado en Cold Spring Harb Perspect Med (2017)

PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor

por Diehl, Katharine L., Ge, Eva J., Weinberg, Daniel N., Jani, Krupa S., Allis, C. David, Muir, Tom W.
Publicado en Proc Natl Acad Sci U S A (2019)

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

por Rajagopalan, Kartik N., Chen, Xiao, Weinberg, Daniel N., Chen, Haifen, Majewski, Jacek, Allis, C. David, Lu, Chao
Publicado en Proc Natl Acad Sci U S A (2021)

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation

por Jones, Morgan, Osawa, Gail, Regal, Joshua A., Weinberg, Daniel N., Taggart, James, Kocak, Hande, Friedman, Ann, Ferguson, David O., Keegan, Catherine E., Maillard, Ivan
Publicado 2013

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

por Jones, Morgan, Chase, Jennifer, Brinkmeier, Michelle, Xu, Jing, Weinberg, Daniel N., Schira, Julien, Friedman, Ann, Malek, Sami, Grembecka, Jolanta, Cierpicki, Tomasz, Dou, Yali, Camper, Sally A., Maillard, Ivan
Publicado en J Clin Invest (2015)

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

por Weinberg, Daniel N., Rosenbaum, Phillip, Chen, Xiao, Barrows, Douglas, Horth, Cynthia, Marunde, Matthew R., Popova, Irina K., Gillespie, Zachary B., Keogh, Michael-Christopher, Lu, Chao, Majewski, Jacek, Allis, C. David
Publicado en Nat Genet (2021)

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

por Jain, Siddhant U., Khazaei, Sima, Marchione, Dylan M., Lundgren, Stefan M., Wang, Xiaoshi, Weinberg, Daniel N., Deshmukh, Shriya, Juretic, Nikoleta, Lu, Chao, Allis, C. David, Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Publicado en Proc Natl Acad Sci U S A (2020)

H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

por Weinberg, Daniel N., Papillon-Cavanagh, Simon, Chen, Haifen, Yue, Yuan, Chen, Xiao, Rajagopalan, Kartik N., Horth, Cynthia, McGuire, John T., Xu, Xinjing, Nikbakht, Hamid, Lemiesz, Agata E., Marchione, Dylan M., Marunde, Matthew R., Meiners, Matt, Cheek, Marcus, Keogh, Michael-Christopher, Bareke, Eric, Djedid, Anissa, Harutyunyan, Ashot S., Jabado, Nada, Garcia, Benjamin A., Li, Haitao, Allis, C. David, Majewski, Jacek, Lu, Chao
Publicado en Nature (2019)