Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

Rapidly cycling fetal and neonatal hematopoietic stem cells (HSCs) generate a pool of quiescent adult HSCs after establishing hematopoiesis in the bone marrow. We report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergen...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Jones, Morgan, Chase, Jennifer, Brinkmeier, Michelle, Xu, Jing, Weinberg, Daniel N., Schira, Julien, Friedman, Ann, Malek, Sami, Grembecka, Jolanta, Cierpicki, Tomasz, Dou, Yali, Camper, Sally A., Maillard, Ivan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463197/
https://ncbi.nlm.nih.gov/pubmed/25866973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78124
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