ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Hematopoietic stem cells (HSC) self-renew to sustain stem cell pools and differentiate to generate all types of blood cells. HSCs remain in quiescence to sustain their long-term self-renewal potential. It remains unclear whether protein quality control is required for stem cells in quiescence when R...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Liu, Lu, Inoki, Ayaka, Fan, Kelly, Mao, Fengbiao, Shi, Guojun, Jin, Xi, Zhao, Meiling, Ney, Gina, Jones, Morgan, Sun, Shengyi, Dou, Yali, Inoki, Ken, Qi, Ling, Li, Qing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Plenary Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770563/
https://ncbi.nlm.nih.gov/pubmed/33150381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007975
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