Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo

Wingless (Wnt) is a potent morphogen demonstrated in multiple cell lineages to promote the expansion and maintenance of stem and progenitor cell populations. Pharmacologic modification of Wnt signaling has been shown to increase hematopoietic stem cells (HSC). We explored the impact of Wnt signaling...

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Bibliografske podrobnosti
Main Authors: Fleming, Heather E, Janzen, Viktor, Celso, Cristina Lo, Guo, Jun, Leahy, Kathleen M, Kronenberg, Henry M, Scadden, David T
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991120/
https://ncbi.nlm.nih.gov/pubmed/18371452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.01.003
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