Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

Notch is long recognized as a signaling molecule important for stem cell self-renewal and fate determination. Here we reveal a novel adhesive role of Notch-ligand engagement in hematopoietic stem and progenitor cells (HSPCs). Using mice with conditional loss of O-fucosylglycans on Notch EGF-like rep...

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Pubblicato in:Stem Cells
Autori principali: Wang, Weihuan, Yu, Shuiliang, Zimmerman, Grant, Wang, Yiwei, Myers, Jay, Yu, Vionnie W.C., Huang, Dan, Huang, Xiaoran, Shim, Jeongsup, Huang, Yuanshuai, Xin, William, Qiao, Peter, Yan, Minhong, Xin, Wei, Scadden, David T., Stanley, Pamela, Lowe, John B., Huang, Alex Y., Siebel, Christian W., Zhou, Lan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478168/
https://ncbi.nlm.nih.gov/pubmed/25851125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2031
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