Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

Notch is long recognized as a signaling molecule important for stem cell self-renewal and fate determination. Here we reveal a novel adhesive role of Notch-ligand engagement in hematopoietic stem and progenitor cells (HSPCs). Using mice with conditional loss of O-fucosylglycans on Notch EGF-like rep...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cells
Prif Awduron: Wang, Weihuan, Yu, Shuiliang, Zimmerman, Grant, Wang, Yiwei, Myers, Jay, Yu, Vionnie W.C., Huang, Dan, Huang, Xiaoran, Shim, Jeongsup, Huang, Yuanshuai, Xin, William, Qiao, Peter, Yan, Minhong, Xin, Wei, Scadden, David T., Stanley, Pamela, Lowe, John B., Huang, Alex Y., Siebel, Christian W., Zhou, Lan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478168/
https://ncbi.nlm.nih.gov/pubmed/25851125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2031
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg