Aberrant Notch signaling in the bone marrow microenvironment of acute lymphoid leukemia suppresses osteoblast-mediated support of hematopoietic niche function

More than half of T-ALL patients harbor gain-of-function mutations in the intracellular domain of Notch1. Diffuse infiltration of the bone marrow commonly occurs in T-ALL and relapsed B-ALL patients, and is associated with worse prognosis. However, the mechanism of leukemia outgrowth in the marrow a...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Wang, Weihuan, Zimmerman, Grant, Huang, Xiaoran, Yu, Shuiliang, Myers, Jay, Wang, Yiwei, Moreton, Stephen, Nthale, Joseph, Awadallah, Amad, Beck, Rose, Xin, Wei, Wald, David, Huang, Alex Y., Zhou, Lan
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794354/
https://ncbi.nlm.nih.gov/pubmed/26801976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2092
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