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Two loops undergoing concerted dynamics regulate activity of the ASH1L histone methyltransferase
ASH1L (Absent, Small, or Homeotic-like 1) is a histone methyltransferase (HMTase) involved in gene activation that is overexpressed in multiple forms of cancer. Previous studies of ASH1L’s catalytic SET domain identified an autoinhibitory loop that blocks access of histone substrate to the enzyme ac...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4664444/ https://ncbi.nlm.nih.gov/pubmed/26292256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00697 |
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