Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing histone H3 lysine 36 (H3K36) methylation(1,2) and is...

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Publicat a:Nat Genet
Autors principals: Weinberg, Daniel N., Rosenbaum, Phillip, Chen, Xiao, Barrows, Douglas, Horth, Cynthia, Marunde, Matthew R., Popova, Irina K., Gillespie, Zachary B., Keogh, Michael-Christopher, Lu, Chao, Majewski, Jacek, Allis, C. David
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283687/
https://ncbi.nlm.nih.gov/pubmed/33986537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00856-5
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