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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin
Diverse accessory subunits are involved in the recruitment of Polycomb Repressive Complex 2 (PRC2) to CpG island (CGI) chromatin. Here we report the crystal structure of a SUZ12-RBBP4 complex bound to fragments of the accessory subunits PHF19 and JARID2. Unexpectedly, this complex adopts a dimeric s...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7571800/ https://ncbi.nlm.nih.gov/pubmed/31959557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.12.019 |
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